High-sensitivity cardiac troponins: detection and central analytical characteristics

High-sensitivity assays for cardiac troponins.

This issue of Clinical Chemistry and Laboratory Medicine (CCLM) devotes a large section to the cardiac troponins (cTn) and in particular to the impact of the novel high sensitivity (hs) assays on clinical practice. Furthermore, several articles deal with known or novel pitfalls of hs-cTn in clinical diagnostics. While there is no doubt that the hs-cTn assays constitute a significant analytical ...

Analytical characteristics of high-sensitivity cardiac troponin assays.

BACKGROUND Cardiac troponins I (cTnI) and T (cTnT) have received international endorsement as the standard biomarkers for detection of myocardial injury, for risk stratification in patients suspected of acute coronary syndrome, and for the diagnosis of myocardial infarction. An evidence-based clinical database is growing rapidly for high-sensitivity (hs) troponin assays. Thus, clarifications of...

Consensus statement on the use of high sensitivity cardiac troponins

The increased sensitivity of high sensitivity cardiac troponin assays comes at a cost of decreased specificity, and “false positive” diagnosis of acute coronary syndromes has made clinicians wary of their use, fearing unnecessary hospitalisations, angiography and revascularisation. The Ethics and Guidelines Standing Committee of SA Heart Association convened a meeting of cardiologists, chemical...

How to use high-sensitivity cardiac troponins in acute cardiac care.

Kristian Thygesen*, Johannes Mair, Evangelos Giannitsis, Christian Mueller, Bertil Lindahl, Stefan Blankenberg, Kurt Huber, Mario Plebani, Luigi M. Biasucci, Marco Tubaro, Paul Collinson, Per Venge, Yonathan Hasin, Marcello Galvani, Wolfgang Koenig, Christian Hamm, Joseph S. Alpert, Hugo Katus, and Allan S. Jaffe, the Study Group on Biomarkers in Cardiology of the ESC Working Group on Acute Car...

Cardiac troponins.